Sitagliptin hoc probato FDA tamquam accessio ad victu et exercitium ut amplio glycemic imperium in aegris cum T2DM aut sicut MONOTHERAPY aut cumulative cum metformin aut peroxisome proliferatoractivated receptor γ agonist (exempli gratia, thiazolidinediones) ubi una agente non glycemic imperium providere sufficiens.
Sitagliptin
Sitagliptin CAS: 486460-32-6
Sitagliptin PHOSPHATE monohydrate CAS: 654671-77-9
Donec Sitagliptin Properties
MF: C16H15F6N5O
MW: 407,31
Liquescens punctum, 114.1-115.7 ° F
Ferventis punctum: 529,9 ± 60.0 ° C (Praedicta)
Density: 1.61 ± 0.1 g / cm3 (Praedicta)
Sitagliptin Specification:
|
items |
Signa |
analyticae results |
|
species |
Off-album ut pulveris whitecrystal |
album crystallinum pulveris |
|
Lepidium sativum |
rt lacustris |
Applica |
|
IR |
Applica |
|
|
PHOSPHATE |
Applica |
|
|
aqua |
3.7% 3.3 ~ |
3.41% |
|
Residuum de ignitis |
â € ¤0.2% |
0,02% |
|
Chiral inmunditia |
â € ¤0.5% |
0.01% |
|
Related menstruatae |
Quid singula impurityâ ¤0.1% |
0.01% |
|
Total impuritiesâ € ¤0.5% |
0,02% |
|
|
silicium primordium |
XCVIII%% -102,0 |
100.2% |
|
RELICTUM menstrua |
ND |
|
|
IPACâ ¤5000ppm |
ND |
|
|
Methanolâ ¤3000ppm |
ND |
|
|
Isopropanolâ ¤5000ppm |
1051ppm |
|
|
PSD |
-100 per XC% XCV% particula micron seive |
Applica |
|
LXIII per LX% -80% particula micron seive |
Applica |
|
|
conclusioni |
Applicas withUSP41standard. |
|
Sitagliptin Proœmium
Sitagliptin est viva voce, quod inventum bioavailable electionem selectivam DPP4 precursor per ipsum de a-genus ofβ Aminoácido propriae DPP4 inhibitors.
Postero die cum hoste actionem DPP4 demittit administrationis modo conservat integras GIP grassentur gradus et post refectionem et acutis et longis GLP1 studiis accreverit hypoglycaemia minuit significationem sine sanguine GLYCOSA campester.
Et applicationem Sitagliptin Italiae Commodum Collegit:
Volume studiis ostenditur quod cetagliptin oris medicamento est efficax ad bonum foro spes. Non habet, hypoglycemic effectus, ubi usus significant sola aut cumulative cum metformin et pioglitazone et non est tutum ut bene tolerari adversa reactiones habet pauci
